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Health-related quality of life in DISCOVER patients at baseline presented at EASD 2018
In another well-received presentation of baseline DISCOVER data, Professor Antonio Nicolucci of the DISCOVER Scientific Committee presented interesting data on the health-related quality of life (HRQoL) of DISCOVER patients in a poster at the 54th Annual Meeting of the EASD in Berlin, Germany, 1–5 October 2018.
HRQoL was assessed using the 36-item Short-Form Health Survey version 2 (SF-36v2) and the Hypoglycaemia Fear Survey-II (HFS-II) questionnaire in 32 and 24 countries, respectively.
Scores for the SF-36v2 questionnaire, for which component summary scores below 50 indicate a lower HRQoL in relation to the 2009 US population, were generally lower in DISCOVER patients than in the general population. Overall, the mean Physical Component Summary (PCS) score of the SF-36v2 was 48.3 compared with the lower mean Mental Component Summary (MCS) score of 46.0, suggesting that type 2 diabetes has a greater impact on mental health than on physical health. This was a consistent pattern across all regions. Factors associated with lower HRQoL were related to disease (e.g. history of macrovascular complications), treatment (e.g. first-line treatment with a sulphonylurea rather than metformin) or other patient characteristics such as sex (female versus male) and education (absence of secondary or higher education and absence of education on type 2 diabetes in the past year). Fear of hypoglycaemia as measured by the HFS-II questionnaire varied greatly among patients, but increased scores were associated with decreased SF-36v2 PCS and MCS scores. Patients living in the Eastern Mediterranean region had higher HFS-II scores than those living in Europe.
These valuable data will help us to understand the impact of type 2 diabetes on HRQoL more thoroughly, with the aim of improving patients’ quality of life as well as clinical outcomes. Thank you to all the DISCOVER investigators for collecting the data that made this presentation possible. For further updates, please keep visiting the DISCOVER website.